This White Paper provides an in-depth review of contemporary capabilities and solutions for effectively integrating third-party CMOs and other suppliers with GMP manufacturing quality systems and operations.  It explores problems with quality oversight in the third party supply chain; how to think differently about managing the third-party supply chain; considering a technology framework to support improved third-party supply chain effectiveness; and how to “make it happen” for your company.    This White Paper will stimulate your thinking and engage readers with questions about changing the game with people-process-technology third party supply chain approaches.